A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/545 (2006.01) A61K 9/08 (2006.01) A61P 31/00 (2006.01) A61P 31/04 (2006.01)
Patent
CA 2417843
The present invention provides for a method of injecting an antibiotic in the ear of an animal, such as cattle, swine, sheep and goats. These injectable antibiotics include the following: injectable suspensions of sparingly water-soluble antimicrobial agents, such as procaine penicillin, benzathine penicillin, ceftiofur crystalline free acid of formula (I), Image ceftiofur hydrochloride, ampicillin trihydrate and amoxicillin trihydrate; sustained-release non-aqueous solutions of sparingly water-soluble antimicrobial agents, such as oxytetracycline, erythromycin, tylosin, tilmicosin and florfenicol; and injectable solutions of zwitterionic antimicrobial agents, such as enrofloxycin, danofloxacin, premafloxacin, ceftiofur sodium, and lincomycin hydrochloride. Specifically, the present invention provides for a method of injecting a relatively large volume (1 to 15 mL) of a sterile oil suspension of an antibiotic, such as ceftiofur crystalline free acid, in the posterior of the ear of cattle and swine. The compound of formula (I) is also named 7-[2-(2-amino-1,3-thiazol-4- yl)-2- methoxyimino)acetamino]-3-[(fur-2-ylcarbonyl)thiomethyl]-3-cephem-4-carboxylic acid.
Macrae & Co.
Pharmacia & Upjohn Company
LandOfFree
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