A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/12 (2006.01) C12N 5/0784 (2010.01) A61K 35/14 (2006.01) A61K 35/26 (2006.01) A61K 35/28 (2006.01) A61K 35/36 (2006.01) A61K 39/00 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01)
Patent
CA 2509058
The present invention provides populations of cells comprising partially matured dendritic cells that can be used for administration individuals having a tumor. Partially matured dendritic cells, those contacted with a dendritic cell maturation agent for about 1 to about 10 hours, or more, efficiently take up and process tumor antigens in the area of the tumor site, complete maturation, and can subsequently migrate to the lymph nodes of a treated individual. Once in the lymph node the now fully mature antigen presenting dendritic cells secrete the appropriate cytokines (e.g., TNF.alpha. and IL-12) and contact T cells inducing a substantial anti-tumor immune response.
L'invention concerne des populations de cellules comprenant des cellules dendritiques partiellement matures pouvant être administrées à des individus présentant une tumeur. Les cellules dendritiques partiellement matures, celles mises en contact avec un agent de maturation de cellule dendritique pendant environ 1 à environ 10 heures, ou plus, fixent et traitent de manière efficace des antigènes tumoraux dans la zone du site de la tumeur, achèvent leur maturation, et peuvent ensuite migrer dans les ganglions lymphatiques d'un individu traité. Une fois dans le ganglion lymphatique, les cellules dendritiques pleinement matures présentant l'antigène sécrètent les cytokines appropriées (par exemple, TNF.alpha. and IL-12), et entrent en contact avec des lymphocytes T, induisant une réponse immunitaire anti-tumorale sensible.
Gowling Lafleur Henderson Llp
Northwest Biotherapeutics Inc.
LandOfFree
Administration of dendritic cells partially matured in vitro... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Administration of dendritic cells partially matured in vitro..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Administration of dendritic cells partially matured in vitro... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-2078840