Administration of histamine for therapeutic purposes

Details Administration of histamine for therapeutic purposes Administration of histamine for therapeutic purposes

A - Human Necessities

61

K

A61K 38/20 (2006.01) A61K 31/20 (2006.01) A61K 31/415 (2006.01) A61K 31/417 (2006.01) A61K 31/675 (2006.01) A61K 38/21 (2006.01) A61K 39/35 (2006.01) A61K 45/06 (2006.01)

Patent

CA 2253365

Methods for obtaining beneficial stable levels of circulating histamine are disclosed for use in methods for enhancing the cytotoxicity of cytotoxic effector cells. In such methods, a beneficial level of circulating histamine is attained and an agent whose ability to enhance natural killer cell cytotoxicity is augmented by histamine is administered. Alternatively, stable beneficial levels of circulating histamine can be attained in subjects receiving chemotherapy or antiviral treatment. The invention may also be employed in treatments combining histamine, agents which enhance the cytotoxicity of cytotoxic effector cells, and chemotherapeutic agents. Optimization of the delivery of histamine and substances which induce the release of endogenous histamine are also disclosed.

L'invention a trait à des procédés, permettant d'obtenir des taux stables bienfaisants d'histamine circulante, utilisables dans des techniques de renforcement de la cytotoxicité de cellules effectrices cytotoxiques. On obtient, au titre de ces procédés, un taux bienfaisant d'histamine circulante, et l'on administre un agent dont l'aptitude à renforcer la cytotoxicité naturelle d'une cellule lytique est accrue par l'histamine. Dans une variante, on obtient, chez des sujets soignés par chimiothérapie ou suivant un traitement antiviral, des taux stables bienfaisants d'histamine circulante. Cette invention peut également servir dans le cas de traitement combinant l'histamine, des agents renforçant la cytotoxicité de cellules effectrices cytotoxiques ainsi que des agents entrant dans une chimiothérapie. L'invention porte également sur l'optimalisation de l'administration d'histamine et de substances provoquant la libération d'histamine endogène.

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