Administration of oligonucleotides antisense to dopamine...

Details Administration of oligonucleotides antisense to dopamine... Administration of oligonucleotides antisense to dopamine...

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) A61K 48/00 (2006.01) A61K 49/00 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01)

Patent

CA 2151585

A method and pharmaceutical preparation are provided for diagnosing and treating pathological conditions related to a dopamine receptor abnormality. The method comprises administering to a patient having such a pathological condition an oligonucleotide antisense to one or more RNA molecules encoding one of the several dopamine receptors. The antisense oligonucleotide bind specifically to expression- controlling sequences of such RNA molecules, thereby selectively controlling expression of one or more dopamine receptor subtypes, and alleviating the pathological conditions related to their

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