Administration of the reg1 anticoagulation system

Details Administration of the reg1 anticoagulation system Administration of the reg1 anticoagulation system

A - Human Necessities

61

K

A61K 31/7088 (2006.01) A61P 7/02 (2006.01) G01G 19/44 (2006.01)

Patent

CA 2653313

An improved method of administration of an aptamer and antidote system to regulate blood coagulation in a host is provided based on weight adjusted or body mass index-adjusted dosing of the components of the system to provide a desired pharmacodynamic response. In addition, a method of reversing activity of the aptamer to a desired extent is provided where an antidote dose is based solely on its relationship to the aptamer dose.

L'invention concerne une méthode améliorée d'administration d'un système constitué d'un aptamère et d'un antidote afin de réguler la coagulation sanguine chez un hôte. Ladite méthode est basée sur un dosage ajusté en fonction du poids ou de l'indice de masse corporelle des composants du système pour obtenir une réponse pharmacodynamique souhaitée. L'invention concerne en outre une méthode d'inversion de l'activité de l'aptamère selon un degré souhaité, dans laquelle une dose d'antidote est basée uniquement sur sa relation avec la dose d'aptamère.

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