Adrenocorticotrophic hormone receptor and uses

Details Adrenocorticotrophic hormone receptor and uses Adrenocorticotrophic hormone receptor and uses

C - Chemistry, Metallurgy

12

N

C12N 15/16 (2006.01) A61K 39/395 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C07K 14/72 (2006.01) C07K 16/18 (2006.01) C07K 16/46 (2006.01) C12N 5/10 (2006.01) C12N 5/26 (2006.01) C12P 21/08 (2006.01) C12Q 1/68 (2006.01) G01N 33/566 (2006.01) G01N 33/74 (2006.01)

Patent

CA 2133845

The present invention relates to a mammalian adrenocorticotropic hormone receptor. The invention is directed toward the isolation, characterization and phar- macological use of mammalian adrenocorticotropic hor- mone receptor, the gene corresponding to this receptor, a recombinant eukaryotic expression construct capable of expressing a mammalian adrenocorticotropic hormone receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that syn- thesize mammalian adrenocorticotropic hormone recep- tor. The invention also provides methods for screening ACTH R agonists and antagonists in vitro using prepar- ations of receptor from such cultures of eukaryotic cells transformed with a recombinant eukaryotic expression construct comprising the ACTH R receptor gene. The in- vention specifically provides human and bovine ACTH R genes.

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