C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/16 (2006.01) A61K 38/04 (2006.01) A61K 38/22 (2006.01) C07K 1/00 (2006.01) C07K 1/107 (2006.01) C07K 1/13 (2006.01) C07K 7/04 (2006.01) C07K 14/575 (2006.01) C07K 16/26 (2006.01) G01N 33/53 (2006.01) G01N 33/74 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2122112
According to the present invention, adrenomedullin which is a novel peptide having a hypotensive effect; proadrenomedullin N-terminal 20 peptide (proAM-N20) corresponding to an amino acid sequence of an N-terminus of proadrenomedullin, having a catecholamine secretion inhibitory effect; proadrenomedullin N-terminal 10-20 peptide (proAM-N(10-20)) having a Na channel inhibitory effect, and a gene encoding these peptides are provided. In addition, according to the present invention, these peptides in a sample containing adrenomdullin or proAM-N20 in an unknown amount can be quantified by using an antibody against adrenomedullin, proAM-N20, or its fragment.
La présente invention porte sur : l'adrénomédulline, nouveau peptide qui a un effet hypotenseur; le peptide proadrénomédulline à N terminal 20 (proAM-N20) correspondant à une séquence d'acides aminés sur un N terminal, exerçant un effet inhibiteur sur la catécholamine; le peptide proadrénomédulline à N terminal 10-20 (proAM-N 10-20), exerçant un effet inhibiteur sur le canal du Na; un gène codant ces peptides. De plus, selon l'invention, ces peptides, présents en quantités inconnues dans un échantillon contenant de l'adrénomédulline ou de la proAM-N20, peuvent être quantifiés grâce à un anticorps de l'adrénomédulline, de la proAM-N20, ou un fragment.
Eto Tanenao
Kangawa Kenji
Kitamura Kazuo
Matsuo Hisayuki
G. Ronald Bell & Associates
Kangawa Kenji
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