Adsls as modifiers of the p53 pathway and methods of use

Details Adsls as modifiers of the p53 pathway and methods of use Adsls as modifiers of the p53 pathway and methods of use

C - Chemistry, Metallurgy

12

Q

C12Q 1/00 (2006.01) A61K 38/17 (2006.01) C12Q 1/02 (2006.01) C12Q 1/527 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2449135

Human ADSL genes are identified as modulators of the p53 pathway, and thus are therapeutic targets for disorders associated with defective p53 function. Methods for identifying modulators of p53, comprising screening for agents that modulate the activity of ADSL are provided.

La présente invention repose sur l'identification du rôle que jouent les gènes ADSL humains comme modulateur du chemin du p53, et qu'ils constituent ainsi des cibles thérapeutiques dans le cas de troubles liés à un défaut de la fonction p53. L'invention concerne également des procédés permettant d'identifier les modulateurs du p53, et notamment la recherche systématique par criblage d'agents modulateurs de l'activité de l'ADSL.

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