Adult sertoli cells and uses thereof

Details Adult sertoli cells and uses thereof Adult sertoli cells and uses thereof

A - Human Necessities

61

K

A61K 35/48 (2006.01) A61K 35/39 (2006.01) A61P 3/10 (2006.01) A61P 37/06 (2006.01)

Patent

CA 2658951

The invention relates, in part, to non-neonatal Sertoli cells derived from non-rodent animals, pharmaceutical compositions comprising such Sertoli cells, and uses thereof. The non-neonatal, non-rodent Sertoli cells express more FasL than neonatal Sertoli cells, and they provide greater immunoprivilege than neonatal Sertoli cells. In some embodiments the Sertoli cells are modified to express a biological factor. In other embodiments, the pharmaceutical compositions further comprise non-Sertoli cells. The invention also provides implantation devices comprising the pharmaceutical compositions, methods of making the pharmaceutical compositions, and methods of using the pharmaceutical compositions by administering an effective amount of the compositions.

L'invention concerne, en partie, des cellules de Sertoli non-néonatales issues d'animaux non-rongeurs, des compositions pharmaceutiques comprenant de telles cellules de Sertoli et des utilisations de celles-ci. Les cellules de Sertoli non-rongeurs, non-néonatales expriment davantage de FasL que des cellules de Sertoli néonatales, et elles fournissent un privilège immunisant supérieur aux cellules de Sertoli néonatales. Dans certains modes de réalisation, les cellules de Sertoli sont modifiées pour exprimer un facteur biologique. Dans d'autres modes de réalisation, les compositions pharmaceutiques comprennent en outre des cellules non-Sertoli. L'invention concerne également des dispositifs d'implantation comprenant les compositions pharmaceutiques, des procédés de fabrication des compositions pharmaceutiques, et des procédés d'utilisation des compositions pharmaceutiques par l'administration d'une quantité efficace des compositions.

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