Adult t cell leukemia model animal

Details Adult t cell leukemia model animal Adult t cell leukemia model animal

A - Human Necessities

01

K

A01K 67/027 (2006.01) C12N 5/10 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2348473

The present invention provides an adult T cell leukemia model animal, which is a T cell function deficient animal to which a cell line infected with human T cell leukemia virus-1 is transplanted. This model animal allows the HTLV-1 infected cell line to proliferate over a long period of time, and enables not only the tumorigenesis process but also the mechanism of onset of ATL and immune response mechanism of the host against ATL to be precisely analyzed.

Modèle animal adulte atteint de la leucémie des lymphocytes T dépourvu de la fonction des lymphocytes T dans lequel on a transplanté des cellules infectées par le virus de type 1 de la leucémie des lymphocytes T humains. Ce modèle animal permet aux cellules infectées par le virus de type 1 de la leucémie des lymphocytes T humains de proliférer sur une durée prolongée, ceci permettant d'effectuer des analyses détaillées non seulement du processus de tumorigénèse mais également du mécanisme de réponse immunitaire de l'hôte à ces dernières, et autres.

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