A - Human Necessities – 61 – M
Patent
A - Human Necessities
61
M
A61M 15/00 (2006.01) B65D 77/00 (2006.01) B65D 81/26 (2006.01) B65D 83/14 (2006.01) A61K 9/00 (2006.01)
Patent
CA 2410004
The invention relates inter alia to a container sealed with a valve, which contains a pharmaceutical aerosol formulation comprising (A) particulate salmeterol xinafoate in suspension in (B) a liquefied propellant gas which is 1,1,1,2,3,3,3-heptafluoro-n-propane or 1,1,1,2-tetrafluoroethane and mixtures thereof; said container characterised in that the formulation is substantially anhydrous and remains so over a period of 12 months when stored at 25 ~C and at relative humidity of 60 %. Preferably the valve is characterised in that it contains one or more valve seals substantially constructed from a polymer of ethylene propylene diene monomer (EPDM).
L'invention concerne, entre autres, un contenant fermé hermétiquement par une valve, qui contient une formulation d'aérosol pharmaceutique comprenant (A) du xinafoate de salmétérol particulaire en suspension dans (B) un gaz propulseur liquéfié, qui est 1,1,1,2,3,3,3-heptafluoro-n-propane ou 1,1,1,2-tétrafluoroéthane et des mélanges de celui-ci. L'invention est caractérisée en ce que la formulation est sensiblement anhydre et le reste pendant une période de douze mois si elle est stockée à 25 ·C, à une humidité relative de 60 %. La valve comporte de préférence un ou plusieurs joints composés sensiblement d'un polymère d'éthylène-propylène diène (EPDM).
Cripps Alan Leslie
Godfrey Anne Pauline
Ottolangui David Michael
Glaxo Group Limited
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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