Aerosol delivery of curcumin

Details Aerosol delivery of curcumin Aerosol delivery of curcumin

A - Human Necessities

61

K

A61K 31/12 (2006.01) A61K 9/00 (2006.01) A61K 9/127 (2006.01)

Patent

CA 2536738

Pharmaceutical compositions suitable for aerosol delivery to a subject that include curcumin dispersed in a lipid vehicle, wherein the lipid has a transition temperature of less than about 15 ~C, are disclosed. In addition, methods of treating a pathological condition in a subject that include providing one of the claimed pharmaceutical compositions and administering the composition to the subject are disclosed. For example, the pathological condition can be a hyperproliferative disease, such as cancer, an inflammatory disease, or a pulmonary disease.

L'invention concerne des compositions pharmaceutiques conçues pour être administrées par aérosol à un sujet comprenant de la curcumine dispersée dans un véhicule lipidique, ledit lipide présentant une température de transition inférieure à 15 ·C. De plus, l'invention concerne des méthodes pour traiter des états pathologiques chez un sujet, comprenant l'utilisation d'une des compositions pharmaceutiques de l'invention et l'administration de la composition à un sujet. Par exemple, un état pathologique peut être une maladie hyperproliférante, telle qu'un cancer, une maladie inflammatoire ou une maladie pulmonaire.

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