Aerosol formulation comprising formoterol in suspension

A - Human Necessities – 61 – K

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A61K 9/72 (2006.01) A61K 31/00 (2006.01) A61K 31/67 (2006.01)

Patent

CA 2540042

A pharmaceutical aerosol formulation comprising formoterol fumarate di-hydrate in suspension, and a steroid in solution, and a propellant, ethanol, and optionally a surfactant, wherein the formoterol fumarate di-hydrate has a water content of about 4.8 to 4.28 % by weight, more particularly about 4.5 to 4.28%. A method of producing the formulation characterized in that the formoterol is dried beforehand to a water content of 4.8 to 4.28%.

Formulation pharmaceutique en aérosol comprenant du formoterol fumarate dihydrate en suspension et un stéroïde en solution, ainsi qu'un propulseur, de l'éthanol et, éventuellement, un tensioactif, le formoterol fumarate dihydrate présentant une teneur en eau d'environ 4,8 à 4,28 % en poids, et plus particulièrement d'environ 4,5 à 4,28 % en poids.

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