Aerosol formulations and devices for increasing libido in...

Details Aerosol formulations and devices for increasing libido in... Aerosol formulations and devices for increasing libido in...

A - Human Necessities

61

K

A61K 9/12 (2006.01) A61K 31/565 (2006.01)

Patent

CA 2372231

The libido of adult human female patients is increased by the intrapulmonary delivery of testosterone. A formulation of testosterone is aerosolized and inhaled into a patient's lungs where particles of testosterone deposits on lung tissue and then enter the patient's circulatory system. The patient's testosterone level is enhanced well above baseline levels for a short period and subsides to baseline levels with normal metabolism thereby providing desired short term effects on enhanced libido without undesirable effects of long term enhanced testosterone levels. Additional formulations are provided including formulations for aerosolized delivery of sildenafil citrate which are delivered to male or female patients.

Selon l'invention, la libido des patientes adultes augmente suite à l'administration intrapulmonaire de testostérone. Une formulation de testostérone est pulvérisée puis inhalée dans les poumons de la patiente, où les particules de testostérone se déposent sur les tissus pulmonaires, puis entrent dans l'appareil circulatoire de la patiente. Pendant une courte durée, les niveau de testostérone de la patiente augmentent bien au-delà les niveaux de base et retombent à ces niveaux de base avec le métabolisme normal, provoquant les effets à courts terme souhaités, à savoir une libido accrue, sans les effets indésirables tels que des niveaux de testostérone longtemps élevés. L'invention concerne également des formulations supplémentaires, y compris des formulations destinées à une administration à des patients homme et femme par pulvérisation de citrate de sildenafil.

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