Aerosol formulations for delivery of dihydroergotamine to...

A - Human Necessities – 61 – K

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A61K 31/48 (2006.01) A61K 9/12 (2006.01) A61K 47/24 (2006.01)

Patent

CA 2538237

Pharmaceutical aerosol formulations of dihydroergotamine, or pharmaceutically acceptable salts thereof, to administer dry powders and propellant suspensions via pulmonary aerosol or nasal spray inhalation. Such formulations may be used for the treatment of various disease states and conditions, including, but not limited to, migraine headaches. The dihydroergotamine particles are produced using a supercritical fluid process. The aerosol formulations disclosed have superior stability, purity and comprise particle of respirable size particularly suitable for pulmonary delivery.

La présente invention concerne des formulations pharmaceutiques d'aérosol de dihydroergotamine, ou de sels de celles-ci, acceptables d'un point de vue pharmaceutique, pour administrer des poudres sèches et des suspensions de propulseur par aérosol pulmonaire ou inhalation par pulvérisation nasale. Ces formulations peuvent être utilisées pour traiter différentes maladies et différents états pathologiques comprenant, entre autres, les migraines. Les particules de dihydroergotamine sont produites au moyen d'un procédé à liquide supercritique. Les formulations d'aérosol de l'invention ont une stabilité et pureté supérieures et comprennent des particules dont la taille leur permet d'être respirées et qui conviennent en particulier à l'administration par voie pulmonaire.

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