A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/00 (2006.01) A61K 31/00 (2006.01) A61K 31/4704 (2006.01) A61K 31/485 (2006.01) A61K 45/06 (2006.01) A61K 47/10 (2006.01)
Patent
CA 2477879
The invention discloses an aerosol pharmaceutical composition comprising a medicament in solution in a mixture of a hydrofluoroalkane propellant and one or more co-solvents wherein the aerosol liquid droplets delivered on actuation of the inhaler have a particle size comprised between 0,5 ~m and 2.5 ~m, with a mass median aerodynamic diameter of about 1-2 ~m and wherein the fine particle fraction is at least 30%.
L'invention concerne une composition pharmaceutique aérosol qui contient un médicament en solution dans un mélange de propulseur d'hydrofluoroalcane et d'un ou de plusieurs co-solvants. Les gouttelettes du liquide aérosol expulsées de l'aérosol sous l'effet de la pression sur l'inhalateur présentent une granulométrie comprise entre 0,5 ?m et 2,5 ?m et un diamètre aérodynamique moyen en masse compris entre environ 1 et 2 ?m, la fraction des particules à granulométrie fine étant d'au moins 30 %.
Brambilla Gaetano
Davies Rebecca Jaine
Ferraris Alessandra
Ganderton David
Lewis David Andrew
Chiesi Farmaceutici S.p.a.
Kirby Eades Gale Baker
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