Aerosol formulations of peptides and proteins

Details Aerosol formulations of peptides and proteins Aerosol formulations of peptides and proteins

A - Human Necessities

61

K

A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61K 38/16 (2006.01) A61K 38/22 (2006.01) A61K 38/28 (2006.01) A61K 38/46 (2006.01) A61K 47/44 (2006.01)

Patent

CA 2206736

A pharmaceutical aerosol formulation comprising (a) a HFA propellant; (b) a pharmaceutically active polypeptide dispersible in the propellant; and (c) a surfactant which is a C8-C16 fatty acid or salt thereof, a bile salt, a phospholipid, or an alkyl saccharide, which surfactant enhances the systemic absorption of the polypeptide in the lower respiratory tract.

L'invention porte sur une préparation pharmaceutique d'aérosol comprenant: a) un propulseur de type hydrofluoroalcane; b) un polypeptide pharmaceutiquement actif dispersé dans le propulseur; c) un tensioactif fait d'un acide gras C8-C16 ou l'un de ses sels, d'un sel biliaire, d'un phospholipide ou d'un alkylsaccharide, ledit tensioactif renforçant l'absorption systémique du polypeptide dans les voies respiratoires inférieures.

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