Aerosolizable pharmaceutical formulation for fungal...

Details Aerosolizable pharmaceutical formulation for fungal... Aerosolizable pharmaceutical formulation for fungal...

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/16 (2006.01) A61K 31/00 (2006.01) A61K 31/496 (2006.01)

Patent

CA 2511555

A method of treating and/or providing prophylaxis against a pulmonary fungal infection comprises delivering an aerosolized pharmaceutical formulation comprising an antifungal agent to the lungs. The method comprises determining the minimum inhibitory concentration of the antifungal agent for inhibiting pulmonary fungal growth. A sufficient amount of the pharmaceutical formulation is administered to maintain for a period of time a target antifungal agent lung concentration that is greater than the determined minimum inhibitory concentration. In one version, the antifungal agent is amphotericin B.

L'invention concerne une méthode de traitement et/ou de prophylaxie d'une infection fongique pulmonaire, consistant à administrer aux poumons une solution pharmaceutique en aérosol contenant un agent antifongique. Ladite méthode consiste à déterminer la concentration inhibitrice minimale de l'agent antifongique pour inhiber la croissance fongique pulmonaire. On administre la formulation pharmaceutique en une quantité suffisante pour maintenir pendant une durée déterminée une concentration d'agent antifongique cible dans les poumons, supérieure à la concentration inhibitrice minimale déterminée. Dans un mode de réalisation, l'agent antifongique est l'amphotéricine B.

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