Aerosols for sinunasal drug delivery

Details Aerosols for sinunasal drug delivery Aerosols for sinunasal drug delivery

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61M 11/00 (2006.01) A61M 15/00 (2006.01) B05B 3/00 (2006.01) B05C 11/02 (2006.01)

Patent

CA 2693078

A pharmaceutical aerosol is disclosed which is suitable for delivering an active compound to the mucosa of the nose, the osteomeatal complex or a paranasal sinus. The pressure of the aerosol is not constant, but pulsates at a frequency from about 10 to 90 Hz. The aerosol is further characterised in that it exhibits a low effective flow rate of less than about 5 litres per minute. The aerosol is, inter alia, suitable for the prevention, management, or treatment of a disease, symptom, or condition affecting the nose or the paranasal sinuses, such as acute and chronic sinusitis.

L'invention porte sur un aérosol pharmaceutique qui est approprié pour administrer un composé actif à la muqueuse du nez, au complexe ostioméatique ou à un sinus paranasal. La pression de l'aérosol n'est pas constante, mais réalise des impulsions à une fréquence d'environ 10 à 90 Hz. L'aérosol est en outre caractérisé en ce qu'il présente un débit efficace faible inférieur à environ 5 litres par minute. L'aérosol est, entre autres, approprié pour la prévention, la gestion ou le traitement d'une maladie, d'un symptôme ou d'un état affectant le nez ou les sinus paranasaux, notamment une sinusite aiguë et chronique.

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