Affinity adsorbents for factor viii and von willebrand's factor

Details Affinity adsorbents for factor viii and von willebrand's factor Affinity adsorbents for factor viii and von willebrand's factor

B - Operations, Transporting

01

J

B01J 20/32 (2006.01) C07D 251/48 (2006.01) C07D 251/50 (2006.01) C07D 251/70 (2006.01) G01N 30/00 (2006.01) G01N 33/86 (2006.01)

Patent

CA 2607858

For the separation, removal, isolation, purification, characterisation, identification or quantification of Factor VIII, von Willebrand's Factor or a protein that is a analogue of either, an affinity adsorbent is used that is a compound of formula (II) wherein one X is N and the other is N, C-C1 or C-CN; A is a support matrix, optionally linked to the triazine ring by a spacer; Y is O, S or NR2; Z is O, S or N-R3; R2 and R3 are each H, C1-6 alkyl, C1-6 hydroxyalkyl, benzyl or .beta.-phenylethyl; B and W are each an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; D is H, OH or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidino or amidino group; or B-D is -CHCOOH-(CH2)3-4-NH2; and R7 is a group bearing a positive charge at neutral pH.

La présente invention concerne la séparation, l'élimination, l'isolation, la purification, la caractérisation, l'identification ou la quantification du facteur VIII, du facteur de von Willebrand ou d'une protéine qui est un analogue de l'un ou de l'autre. L'invention utilise dans ce but un adsorbant d'affinité qui est un composé de formule (II) dans laquelle un X est N et l'autre est N, C-Cl ou C-CN; A est une matrice de soutien, facultativement liée au cycle triazine par un espaceur; Y est O, S ou NR2; Z est O, S ou N-R3; R2 et R3 sont chacun H, alkyle en C1-6, hydroxyalkyle en C1-6, benzyle ou ß-phényléthyle; B et W sont chacun une liaison hydrocarbure facultativement substituée contenant de 1 à 10 atomes de carbone; D est H, OH ou un groupe amino primaire, amino secondaire, amino tertiaire, ammonium quaternaire, imidazole, guanidino or amidino; ou B-D est -CHCOOH-(CH2)3-4-NH2; et R7 est un groupe portant une charge positive à pH neutre.

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