Affinity adsorbents for fibrinogen

Details Affinity adsorbents for fibrinogen Affinity adsorbents for fibrinogen

B - Operations, Transporting

01

J

B01J 20/32 (2006.01) C07D 251/50 (2006.01) C07K 14/75 (2006.01) G01N 30/00 (2006.01) G01N 33/86 (2006.01)

Patent

CA 2607863

For the separation, removal, isolation, purification, characterisation, identification or quantification of fibrinogen or a protein that is a fibrinogen analogue, an affinity adsorbent is used that is a compound of formula II wherein one X is N and the other is N, C-Cl or C-CN; Y is O, S or NR2; 0 Z is O, S or NR3; R2 and R3 are each H, alkyl, hydroxyalkyl, benzyl or .beta.-phenylethyl; n is 0 to 6; A is a support matrix, optionally linked to the triazine ring by a spacer; R7 is a group bearing a positive charge at neutral pH; W is an optional linker; V is an aromatic group; and R8 and R9 are each H, OH, alkyl, alkoxy, amino, NH2, acyloxy, acylamino, CO2H, sulphonic acid, carbamoyl, sulphamoyl, alkylsulphonyl or halogen or a cyclic structure such as a morpholino group, or R8 and R9 are linked to form such a cyclic structure.

La présente invention concerne la séparation, l'élimination, l'isolation, la purification, la caractérisation, l'identification ou la quantification du fibrinogène ou d'une protéine qui est un analogue du fibrinogène. L'invention utilise dans ce but un adsorbant d'affinité qui est un composé de formule II dans laquelle un X est N et l'autre est N, C-Cl ou C-CN ; Y est O, S ou NR2 ; 0 Z est O, S ou NR3 ; R2 et R3 sont chacun H, alkyle, hydroxyalkyle, benzyle ou ß-phényléthyle ; n est de 0 à 6 ; A est une matrice de soutien, facultativement liée au cycle triazine par un espaceur ; R7 est un groupe portant une charge positive à pH neutre ; W est un lieur facultatif ; V est un groupe aromatique ; et R8 et R9 sont chacun H, OH, alkyle, alcoxy, amino, NH2, acyloxy, acylamino, CO2H, acide sulfonique, carbamyle, sulfamyle, alkylsulfonyle ou halogène ou une structure cyclique telle qu'un groupe morpholino, ou R8 et R9 sont liés pour former une telle structure cyclique.

Affiliated with

Also associated with

Rating

Affinity adsorbents for fibrinogen does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Affinity adsorbents for fibrinogen, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Affinity adsorbents for fibrinogen will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1481228