Affinity adsorbents for plasminogen

Details Affinity adsorbents for plasminogen Affinity adsorbents for plasminogen

B - Operations, Transporting

01

J

B01J 20/32 (2006.01) C07D 251/48 (2006.01) C07D 251/50 (2006.01) G01N 30/00 (2006.01)

Patent

CA 2607851

For the separation, removal, isolation, purification, characterisation, identification or quantification of plasminogen or a protein that is a plasminogen analogue, an affinity adsorbent is used that is a compound of formula (II) wherein one X is N and the other is N, C-Cl or C-CN; A is a support matrix, optionally linked to the triazine ring by a spacer; Z is O, S or N-R and R is H, C1-6 alkyl, C1-6 hydroxyalkyl, benzyl or .beta.- phenylethyl; B is an optionally substituted hydrocarbon linkage containing from 1 to 10 carbon atoms; D is H, OH or a primary amino, secondary amino, tertiary amino, quaternary ammonium, imidazole, guanidino or amidino group; or B-D is -CHCOOH-(CH2)3-4-NH2; and q is 2 to 6.

La présente invention concerne la séparation, l'élimination, l'isolation, la purification, la caractérisation, l'identification ou la quantification du plasminogène ou d'une protéine qui est un analogue du plasminogène. L'invention utilise dans ce but un adsorbant d'affinité qui est un composé de formule (II) dans laquelle un X est un N et l'autre est un N, un C-Cl ou un C-CN ; A est une matrice de soutien, facultativement liée au cycle triazine par un espaceur ; Z est un O, un S ou un N-R et R est un H, un alkyle en C1-6, un hydroxyalkyle en C1-6, un benzyle ou un .beta.-phényléthyle ; B est une liaison hydrocarbure facultativement substituée contenant de 1 à 10 atomes de carbone ; D est un H, un OH ou un groupe amino primaire, amino secondaire, amino tertiaire, ammonium quaternaire, imidazole, guanidino or amidino ; ou B-D est -CHCOOH-(CH2)3-4-NH2 ; et q est de 2 à 6.

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