Affinity chromatography matrix useful in purifying...

Details Affinity chromatography matrix useful in purifying... Affinity chromatography matrix useful in purifying...

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) B01J 20/32 (2006.01) C07K 5/02 (2006.01) C07K 17/06 (2006.01)

Patent

CA 2075682

163/CCP77 185/CCP78 18506 TITLE OF THE INVENTION AFFINITY CHROMATOGRAPHY MATRIX USEFUL IN PURIFYING INTERLEUKIN-l.beta. CONVERTING ENZYME ABSTRACT OF THE INVENTION Affinity chromatography matrices are disclosed which are useful in purifying interleukin-l.beta. converting enzyme (ICE) from crude or partially purified cell lysate preparations. The chromatographic matrices comprise a specific ICE inhibitor of Formula I which is attached to an affinity column support by means of a bifunctional spacer. Image I

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