Affinity chromatography matrix with built-in reaction indicator

C - Chemistry – Metallurgy – 07 – F

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195/128, 23/338,

C07F 7/10 (2006.01) B01D 15/08 (2006.01) B01J 20/291 (2006.01) B01J 20/32 (2006.01) C12N 9/76 (2006.01) G01N 33/552 (2006.01)

Patent

CA 1222509

B-1281 AFFINITY CHROMATOGRAPHY MATRIX WITH BUILT-IN REACTION INDICATOR Abstract of the Disclosure p-Nitrophenylester of succinoylaminopropyl silica gel is useful as an affinity matrix for react- ing with ligand for use in affinity chromatography. The affinity matrix, upon reaction with a ligand, releases one molecule of p-nitrophenolate ion for every molecule of ligand that reacts and the solution turns yellow as the reaction occurs.

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