Affinity matrix bearing tumor-associated antigens

Details Affinity matrix bearing tumor-associated antigens Affinity matrix bearing tumor-associated antigens

G - Physics

01

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G01N 33/574 (2006.01) A61K 39/395 (2006.01) A61K 51/00 (2006.01) C07K 16/00 (2006.01) C07K 16/06 (2006.01) C07K 16/18 (2006.01) C07K 16/30 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2401580

An affinity matrix having a tumor-associated carbohydrate- or glycopeptide- based antigen bound to the matrix is provided. The affinity matrix is used to isolate, characterize, and quantitate functional antibodies or antigen-binding molecules to the tumor-associated carbohydrate- or glycopeptide-based antigen. The invention also provides a method of preparing the affinity matrix. In addition the invention provides for diagnostic and therapeutic uses of the isolated antibodies or antigen-binding molecules.

La présente invention concerne une matrice d'affinités à laquelle est lié un antigène à base de glucide ou de glycopeptide associé à la tumeur. La matrice d'affinités sert à isoler, caractériser et quantifier des antigènes fonctionnels ou de molécules de liaison à l'antigène avec spécifique de l'antigène à base de glucide ou de glycopeptide associé à la tumeur. L'invention concerne également un procédé pour la préparation de la matrice d'affinités. L'invention concerne enfin des utilisations en diagnostic et en thérapie d'anticorps isolés ou de molécules de liaison à l'antigène.

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