Affinity maturation by competitive selection

Details Affinity maturation by competitive selection Affinity maturation by competitive selection

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61K 38/00 (2006.01) C07H 21/04 (2006.01) C12N 15/00 (2006.01) C12N 15/09 (2006.01) C12N 15/34 (2006.01) C12N 15/63 (2006.01) C12N 15/70 (2006.01) C12Q 1/02 (2006.01) G01N 33/53 (2006.01) G01N 33/537 (2006.01) G01N 33/543 (2006.01) G01N 33/567 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2427747

The present invention provides a method of selecting binding pair members with enhanced binding affinity for the cognate binding partner relative to a reference binding pair member (see Figure 2). In particular, the invention provides methods of selecting antibodies with enhanced affinity for antigen relative to a reference antibody. This process, "affinity maturation", thereby provides antibodies with superior binding capabilities.

La présente invention concerne un procédé permettant de sélectionner des éléments de paires de liaison présentant une meilleure affinité de liaison pour le partenaire de liaison correspondant par rapport à un élément de paire de liaison de référence. En particulier, l'invention concerne des procédés permettant de sélectionner des anticorps possédant une meilleure affinité pour un antigène par rapport à un anticorps de référence. Ce processus de "maturation d'affinité" permet ainsi d'obtenir des anticorps aux capacités de liaison supérieures.

Affiliated with

Also associated with

Rating

Affinity maturation by competitive selection does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Affinity maturation by competitive selection, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Affinity maturation by competitive selection will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1358755