Afucosylated antibodies against ccr5 and their use

Details Afucosylated antibodies against ccr5 and their use Afucosylated antibodies against ccr5 and their use

C - Chemistry, Metallurgy

07

K

C07K 16/28 (2006.01) A61K 39/395 (2006.01)

Patent

CA 2710912

An antibody binding to CCR5 and being glycosylated with a sugar chain at Asn297, said antibody being characterized in that the amount of fucose within said sugar chain is 65 % or lower has improved properties in anti-inflammatory therapy.

La présente invention concerne un anticorps se liant à CCR5 et étant glycosylé avec une chaîne de sucre à Asn297, ledit anticorps étant caractérisé en ce que la quantité de fucose à l'intérieur de ladite chaîne de sucre est de 65 % ou moins et possédant des propriétés améliorées en thérapie anti-inflammatoire.

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