Age formation inhibitors

Details Age formation inhibitors Age formation inhibitors

C - Chemistry, Metallurgy

07

D

167/211, 167/234

C07D 277/48 (2006.01) A61K 31/425 (2006.01) C07D 417/04 (2006.01) C07D 417/12 (2006.01)

Patent

CA 2003220

28138-8 ABSTRACT OF THE DISCLOSURE Thiourea compounds represented by the general formula: Image [I] [wherein A is an aromatic ring group which may be substituted; R1 is a hydrogen atom or a lower alkyl or aryl group which may be substited, or may combine with A to form a cyclic ring; and -COB is an acyl group of a carboxylic acid or an esterified carboxyl group] or salts thereof are provided as agents for inhibiting the formation of AGE (Advanced Glycosidation End product) which are employable for treating diseases caused by AGE-formation, such as diabetic complications, senile cataract, atherosclerosis etc. The compounds of the formula [I] are novel, provided that, when A is a phenyl group which may be substituted or A combines with R1 to form a cyclic ring, B is not a phenyl group which may be substituted; and can be produced by reacting the corresponding aminothiazole compounds with isocyanate compounds having the formula of BCONCS (wherein B is the same as above).

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