Agent administration

Details Agent administration Agent administration

A - Human Necessities

61

K

A61K 9/24 (2006.01) A61K 31/4184 (2006.01) A61K 31/7048 (2006.01) A61K 33/04 (2006.01) A61K 33/24 (2006.01) A61P 33/10 (2006.01) A61D 7/00 (2006.01)

Patent

CA 2600960

An intra-ruminal bolus and method of manufacture is described that releases a therapeutically effective amount of at least one beneficial agent to a ruminant animal over a time period of less than approximately 21 days. The bolus includes at least one beneficial agent, at least one densifier material, at least one binding agent, and at least one releasing agent. The bolus is manufactured using a ratio of binding agent to releasing agent that is tailored to achieve the desired rate of reléase and timing of delivery. This ratio is in the order of approximately 1 part binding agent to between approximately 0.01 and approximately 2 parts releasing agent and may be varied within this range in order to obtain the preferred reléase length of time. The bolus is particularly useful for delivery of anti-parasitic compounds but may also be used for delivery of other active agents such as trace elements including selenium and cobalt.

L~invention concerne un bolus intra-ruminal et une méthode de fabrication qui émet une quantité efficace d~un point de vue thérapeutique d~au moins un agent bénéfique à un animal ruminant au cours d~une période de temps inférieure à environ 21 jours. Le bolus comprend au moins un agent bénéfique, au moins un matériau densificateur, au moins un agent de liaison et au moins un agent d'émission. Le bolus est fabriqué avec une proportion d~agent de liaison et d~agent d'émission qui est adaptée pour obtenir un taux d'émission et un moment d'émission recherchés. Cette proportion est de l~ordre d'environ 1 part d~agent de liaison pour entre environ 0,01 et environ 2 parts d~agent d'émission et peut varier sur cet intervalle afin d~obtenir le moment d'émission choisi. Le bolus est particulièrement utile pour réaliser l'émission de composés anti-parasitaires mais il peut aussi être utilisé pour l'émission d~autres agents actifs comme les oligo-éléments y compris le sélénium et le cobalt.

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