Agent and method for treatment of cancer

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 31/704 (2006.01) A61K 31/706 (2006.01) A61K 35/14 (2006.01) A61K 38/21 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2689242

[PROBLEMS] To provide a technique which enables an effective antibody therapy for cancer which targets for FGFR1 without the need of using any effective antibody having high specificity and a potent cell-killing activity. [MEANS FOR SOLVING PROBLEMS] Disclosed are: a therapeutic agent for cancer, which comprises an enhancer of the expression of a fibroblast growth factor receptor-1 and an anti-fibroblast growth factor receptor-1 antibody; and a method for the treatment of cancer using the therapeutic agent.

Le problème à résoudre dans le cadre de la présente invention est de fournir une technique permettant d'obtenir une thérapie anticancéreuse basée sur des anticorps efficaces, ciblant FGFR1 sans recourir à un quelconque anticorps efficace, avec une spécificité élevée et une importante activité d'élimination cellulaire. La solution proposée consiste à fournir un agent thérapeutique contre le cancer qui comprend un amplificateur de l'expression d'un récepteur-1 du facteur de croissance de fibroblaste et d'un anticorps du récepteur-1 de facteur de croissance d'anti-fibroblaste. L'invention concerne également un procédé de traitement du cancer utilisant ledit agent thérapeutique.

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