Agent comprise an albumin-like first polypeptide bound to a...

Details Agent comprise an albumin-like first polypeptide bound to a... Agent comprise an albumin-like first polypeptide bound to a...

C - Chemistry, Metallurgy

12

N

C12N 15/62 (2006.01) A61K 38/38 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 13/12 (2006.01) C07K 14/76 (2006.01) C07K 19/00 (2006.01) C12N 1/21 (2006.01) C12N 5/10 (2006.01) C12N 15/14 (2006.01) C12N 15/63 (2006.01) C12N 15/86 (2006.01) C12P 21/02 (2006.01)

Patent

CA 2519027

An agent having a greater half-life than naturally produced albumin in a patient with NS, the agent comprising an albumin-like first polypeptide bound to a second polypeptide, wherein the second polypeptide, when bound to the albumin-like first polypeptide is therapeutically inert and wherein if the agent consists of two albumin molecules, then they are covalently joined to one another other than solely by means of one or more cysteine-cysteine disulphide bridges.

L'invention concerne un agent qui a une durée de vie plus longue qu'une albumine fabriquée naturellement chez un patient avec NS, l'agent comprenant un premier polypeptide similaire à l'albumine lié à un deuxième polypeptide, le deuxième polypeptide, lorsqu'il est lié au premier polypeptide similaire à l'albumine, étant inerte du point de vue thérapeutique; si l'agent est composé de deux molécules d'albumine, celles-ci peuvent être jointes par covalence, au moyen d'un procédé autre que celui utilisant un ou plusieurs ponts bisulfure cystéine-cystéine.

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