Agent containing ergolin for transdermal application

Details Agent containing ergolin for transdermal application Agent containing ergolin for transdermal application

A - Human Necessities

61

K

A61K 9/70 (2006.01) A61K 47/10 (2006.01)

Patent

CA 2504885

The invention relates to a transdermal, therapeutic system containing an ergolin compound, preferably lisuride, in which the ergolin compound is stabilised. The oxidation-sensitive ergolin compound is stabilised by a combination of at least one liposoluble, free-radical scavenging anti-oxidant, preferably di-tert.-butyl methyl phenol, di-tert.-butyl methoxyphenol, tocopherol or ubiquinone and a basic polymer.

L'invention concerne un système thérapeutique transdermique renfermant des composés d'ergoline, de préférence un lisuride, système dans lequel le composé d'ergoline est stabilisé. La stabilisation du composé d'ergoline s'effectue par combinaison d'au moins un antioxydant liposoluble, capteur de radicaux, de préférence, des di-tert.-butylphénols, des di-tert.-butylméthoxyphénols, des tocophérols ou des ubiquinones, et un polymère basique.

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