Agent containing fused protein of soluble rankl with epitope...

Details Agent containing fused protein of soluble rankl with epitope... Agent containing fused protein of soluble rankl with epitope...

C - Chemistry, Metallurgy

12

N

C12N 5/077 (2010.01) C12N 5/078 (2010.01) A61K 38/17 (2006.01) C07K 19/00 (2006.01) C12N 15/09 (2006.01) C12Q 1/00 (2006.01) A01K 67/027 (2006.01) C07K 14/705 (2006.01)

Patent

CA 2666415

It is intended to provide a reagent containing a fused protein of RANKL with an epitope tag which has an improved effect of differentiating and activating osteoclasts compared with the case of using RANKL alone and an improved storage stability. An agent of differentiating and activating osteoclasts in vitro or in vivo which contains a fused protein of soluble RANKL with an epitope tag peptide as the active ingredient.

L'invention concerne un réactif contenant une protéine fusionnée de RANKL avec un marqueur d'épitope qui présente un effet amélioré de différenciation et d'activation des ostéoclastes par comparaison avec le cas où RANKL est utilisé seul, et une stabilité au stockage améliorée. L'invention concerne également un agent de différenciation et d'activation des ostéoclastes in vitro ou in vivo qui contient une protéine fusionnée de RANKL soluble avec un peptide de marqueur d'épitope comme ingrédient actif.

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