Agent-enriched nanoparticles based on hydrophilic proteins

A - Human Necessities – 61 – K

Patent

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Details

A61K 9/14 (2006.01) A61K 47/42 (2006.01)

Patent

CA 2646447

The invention relates to agent-enriched nanoparticles that are based on a hydrophilic protein or a combination of hydrophilic proteins in which functional proteins or peptide fragments are bound to the nanoparticles via polyethylene glycol-.alpha.-maleic acid imide-.omega.-NHS esters. Also disclosed are methods for producing said nanoparticles and the use thereof.

L'invention concerne des nanoparticules chargées d'agent actif, à base d'une protéine hydrophile ou d'une combinaison de protéines hydrophiles. Selon l'invention, des protéines fonctionnelles ou des fragments de peptides fonctionnels sont liés aux nanoparticules par un polyéthylènglykol-.alpha.-maléimid-.omega.-NHS-ester. L'invention porte également sur des procédés pour les réaliser et sur leur utilisation.

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