Agent for binding a plurality of c-reactive protein and...

A - Human Necessities – 61 – K

Patent

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Details

A61K 47/48 (2006.01) A61K 49/00 (2006.01)

Patent

CA 2485852

An agent for use in medicine, which agent comprises a plurality of ligands covalently co-linked so as to form a complex with a plurality of C-reactive protein (CRP) molecules in the presence thereof, wherein (i) at least two of the ligands are the same or different and are capable of being bound by ligand binding sites present on the CRP molecules; or (ii) at least one of the ligands is capable of being bound by a ligand binding site present on a CRP molecule, and at least one other of the ligands is capable of being bound by a ligand binding site present on a serum amyloid P component (SAP) molecule.

L'invention concerne un agent, utilisé en médecine, comprenant une pluralité de ligands co-liés par covalence afin de former un complexe avec une pluralité de molécules de protéine C-réactive (CRP) en présence dudit agent. Au moins deux des ligands sont identiques ou différents et capables d'être liés à l'aide des sites de liaison de ligands présents sur les molécules CPR; ou au moins l'un des ligands est capable d'être lié à l'aide d'un site de liaison de ligands présent sur une molécule CRP, au moins un autre des ligands étant capable d'être lié à l'aide d'un site de liaison de ligands présent sur une molécule de composant amyloïde sérique P (SAP).

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