Agent for curing neuronal diseases

Details Agent for curing neuronal diseases Agent for curing neuronal diseases

A - Human Necessities

61

K

A61K 31/535 (2006.01) A61K 9/127 (2006.01) A61K 31/5375 (2006.01) C07D 295/125 (2006.01) C07D 295/13 (2006.01)

Patent

CA 2168877

Disclosed is an agent for curing neuronal diseases caused by disorders of peripheral nervous system or central nervous system, which comprises a 2-acylaminopropanol derivative represented by the formula (I): Image [wherein R1 represents a phenyl group or cyclohexyl group each of which may be substituted by 1 to 3 same or different substituents selected from the group consisting of alkyl, alkoxy, hydroxy and nitro, or represents an alkyl group, and n represents an integer of 0 to 16] or a pharmaceutically acceptable salt thereof as an effective ingredient. It accelerates neurite extension and synapse formation by elevating biosynthesis of endogenous sphingoglycolipid of neurocytes, particularly ganglioside, whereby it can be used for curing various diseases of central nervous system and peripheral nervous system.

Est décrit un remède contre les maladies nerveuses provoquées par des troubles du système nerveux central ou périphérique, contenant comme principe actif un dérivé de 2-acylaminopropanol représenté par la formule générale (I), ou bien un sel pharmaceutiquement acceptable de celui-ci. Dans cette formule, R<1> représente alkyle ou bien phényle ou cyclohexyle qui peuvent être tous les deux substitués par un à trois substituants identiques ou différents choisis dans le groupe composé d'alkyle, alcoxy, et nitro. Ce remède s'utilise pour traiter diverses maladies du système nerveux central et périphérique par induction de la biosynthèse des glycosphingolipides endogènes, notamment un ganglioside, pour ainsi accélérer l'extension des axons et la formation des synapses.

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