Agent for enhancing anti-tumor effect comprising oxaliplatin...

A - Human Necessities – 61 – K

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Details

A61K 31/513 (2006.01) A61K 9/127 (2006.01) A61K 31/282 (2006.01) A61K 31/4412 (2006.01) A61K 31/53 (2006.01) A61K 47/24 (2006.01) A61K 47/34 (2006.01) A61P 35/00 (2006.01) A61P 43/00 (2006.01)

Patent

CA 2713673

An object of the present invention is to further enhance the antitumor effect when oxaliplatin is administered in combination with a combination drug containing tegafur, gimeracil and oteracil potassium. According to the present invention, by using oxaliplatin encapsulated in a liposome preparation, combination therapy of oxaliplatin plus a combination drug containing tegafur, gimeracil and oteracil potassium, is revealed to show remarkably enhanced antitumor effect without increasing side effects.

L'objet de l'invention est d'améliorer davantage l'effet antitumoral lorsque de l'oxaliplatine est utilisée en association avec une préparation mixte qui contient du tégafur, du gimeracil et de l'oteracil potassium. En utilisant de l'oxaliplatine sous la forme d'une préparation de liposome, lorsque la préparation de liposome est utilisée en association avec une préparation mixte contenant du tégafur, du gimeracil et de l'oteracil potassium, l'effet antitumoral peut être amélioré de façon importante sans accroître les effets secondaires indésirables.

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