C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/4738 (2006.01) A61K 31/4745 (2006.01) A61K 31/498 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2392993
Agents for improving learning or memory which are useful in treating dementia in association with dysmnesia caused by cerebrovascular disorder, nerve degeneration diseases such as Alzheimer's disease, endocrine diseases, nutritional/metabolic errors, tumor, infectious diseases, drug poisoning, etc. These agents contain as the active ingredient isoquinoline derivatives having a specific structure (for example, (4aR,12aR)-2-methyl-4a-(3-hydroxyphenyl)- 1,2,3,4,4a,5,12,12a-octahydro-quinoline[2,3-g]isoquinoline) or pharmacologically acceptable salts thereof.
L'invention concerne des agents permettant de stimuler l'apprentissage ou la mémoire. Ces agents sont utiles dans le traitement de la démence associée à la dysmnésie causée par un trouble cérébro-vasculaire, des maladies dégénératives nerveuses telles que la maladie d'Alzheimer, des maladies endocriniennes, des erreurs nutritionnelles/métaboliques, une tumeur, des maladies infectieuses, une intoxication, etc. Lesdits agents contiennent, en tant qu'ingrédient actif, des dérivés d'isoquinoline présentant une structure spécifique (par exemple, (4aR, 12aR)-2-méthyl-4a-(3-hydroxyphényl)-1,2,3,4,4a,5,12,12a-octahydro-quinoline[2,3-g]isoquinoline) ou un sel pharmaceutiquement acceptable desdits composés.
Hirano Noriyuki
Kamei Junzo
Kawamura Kuniaki
Nagase Hiroshi
Smart & Biggar
Toray Industries Inc.
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