Agent for inhibiting cytokinin signaling

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 239/84 (2006.01) A01G 7/06 (2006.01) A01N 43/54 (2006.01) A01P 21/00 (2006.01) C07D 405/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/50 (2006.01) C07K 14/415 (2006.01)

Patent

CA 2669275

Disclosed are: a substance which has an activity of inhibiting the intracellular signaling from a plant-derived cytokinin receptor and which can control the growth or differentiation of a plant. Also disclose is a method for searching for a chemical substance capable of promoting the growth of a root of a plant, which comprises measuring the level of intracellular signaling from the receptor in a system where a cell having the receptor is contacted with a chemical substance having an agonistic activity on the receptor and a substance to be tested, comparing the level of intracellular signaling measured in the preceding step with a level of intracellular signaling measured in the absence of the chemical substance, and determining the chemical substance as being a chemical substance capable of promoting the growth of a root of a plant based on the difference obtained by the comparison; and others.

L'invention concerne : une substance qui a une activité d'inhibition de la signalisation intracellulaire issue d'un récepteur de la cytokinine dérivée d'une plante, et qui peut contrôler la croissance ou la différenciation d'une plante. L'invention concerne également un procédé de recherche d'une substance chimique capable de stimuler la croissance d'une racine ou d'une plante, qui comprend la mesure du niveau de signalisation intracellulaire issue du récepteur, dans un système où une cellule possédant ce récepteur est en contact avec une substance chimique exerçant une activité agonistique sur le récepteur et constituant une substance à tester, en comparant le niveau de signalisation intracellulaire mesuré durant l'étape précédente à un niveau de signalisation intracellulaire mesuré en l'absence de cette substance chimique, et en déterminant que la substance chimique est une substance chimique capable de stimuler la croissance d'une racine ou d'une plante en se basant sur la différence résultant de cette comparaison ; entre autres.

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