C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/11 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2515243
The present invention concerns inhibition of the activity of PLK1, which seems to be connected with cancer growth. Duplex RNAs antisense oligonucleotides and inhibitory peptides have been found to be useful in such inhibition, therefor they are claimed as ingredients fo pharmaceutical compositions for the treatment of proliferative diseases, preferably cancer of various types.
L'invention concerne l'inhibition de l'activité de la PLK1, qui semble être liée au développement du cancer. L'invention concerne également des oligonucléotides antisens à ARN duplex et des peptides inhibiteurs qui se sont révélés utiles dans ladite inhibition. Ces oligonucléotides et peptides sont donc utilisés en tant qu'ingrédients de compositions pharmaceutiques destinées au traitement des maladies prolifératives, en particulier de divers types de cancers.
Spaenkuch-Schmitt Birgit
Strebhardt Klaus
Yuan Juping
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Strebhardt Klaus
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