A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/47 (2006.01)
Patent
CA 2150546
The present invention provides agents for inhibiting production of interleukin- 8 and for inhibiting granulocytes activation as well as novel method for curing inflammatory diseases. The agents for inhibiting production of interleukin-8, and for inhibiting granulocytes activation and for curing inflammatory diseases, which contain as an active ingredient, a carbostyril derivative represented by general formula (I) (wherein R is a halogen atom; the substitution site of a side-chain of formula (A) is 3- or 4-position in the carbostyril skeleton; and the carbon-carbon bond between 3- and 4- positions in the carbostyril skeleton is a single bond or a double bond) or pharmaceutically acceptable salt thereof.
La présente invention concerne des agents inhibant la production d'interleukine-8 et l'activation granulocytaire, ainsi qu'un nouvveau procédé pour guérir des maladies inflammatoires. Ces agents contiennent comme principe actif un dérivé de carbostyryle représenté par la formule (I), ou bien un sel pharmaceutiquement acceptable de celui-ci. Dans ladite formule, R est un atome d'halogène, le site de substitution d'une chaîne latérale de formule (A) est la position 3 ou 4 du squelette de carbostyryle; et la liaison carbone-carbone entre les positions 3 et 4 du squelette de carbostyryle est une liaison simple ou une liaison double.
Aihara Miki
Imagawa Ken-Ichi
Kikuchi Mikio
Matsuda Takahide
Muta Hiroshi
Fetherstonhaugh & Co.
Otsuka Pharmaceutical Co. Ltd.
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