Agent for intravascular administration

C - Chemistry – Metallurgy – 08 – B

Patent

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167/163, 260/212

C08B 31/00 (2006.01) A61K 9/16 (2006.01) A61K 49/00 (2006.01) C08B 33/00 (2006.01) C08B 35/00 (2006.01)

Patent

CA 1037950

ABSTRACT An agent suitable for intravascular administration comprising a suspension of minute particles, is provided, said particles having a size such that subsequent to their intravascular administration they block the finer blood vessels of the body. The suspension is more stable than those previously available, and not as subject to sedimentation. The particles of the suspension decompose in sufficient time to avoid the serious consequences arising from a prolonged blockage of the blood vessels. In addition, the suspension is resistant to heat and fluctuations in temperature. The agent consists of a suspension of minute particles which comprise a polysaccharide built up of glucose units or a physiologically acceptable derivative of said polysaccharide in a physiologically acceptable aqueous liquid. The particles comprise a water-insoluble, but hydrophilic, swellable, three-dimensional network of molecules of the polysaccharide, or of the derivative thereof, cross-linked by means of bridges having bonds of a covalent nature. Said network may be broken up by x-anylase in blood plasma into water-soluble fragments within a time after injection that can be varied within wide limits. The agent is produced by suspending the minute particles in a physiologically acceptable aqueous liquid.

228793

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