C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) A61K 38/18 (2006.01) A61K 38/55 (2006.01) A61K 48/00 (2006.01) C07K 14/51 (2006.01) C07K 14/81 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2406590
The invention relates to an agent for the production of a medicament which is used postoperatively after the removal of bone tumours. The inventive agent is produced from a nucleic acid. A sequence known per se for promoting bone growth and a protease inhibitor also known per se are bonded by means of a variable spacer molecule. Said bonding results in a novel bifunctional active substance which combines both properties in one biological molecule. The invention is used in medecine, particularly in the specialist field of orthopaedics.
L'invention concerne un agent qui sert à produire un médicament à utilisation postopératoire après l'élimination de tumeurs osseuses et qui est produit à partir d'un acide nucléique par combinaison d'une séquence connue en soi servant à la stimulation de la croissance osseuse et d'un inhibiteur de protéase connu en soi par l'intermédiaire d'une molécule d'espacement variable. On obtient, grâce à cette combinaison, un nouveau principe actif bifonctionnel qui réunit les deux propriétés dans une molécule biologique. L'invention est utilisée dans le domaine médical, notamment en orthopédie.
Maubach Gunter
Wiederanders Bernd
Depuy Biotech Jena Gmbh
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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