Agent for preventing or treating portal hypertension

A - Human Necessities – 61 – K

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Details

A61K 31/4245 (2006.01) A61K 31/41 (2006.01) A61K 31/4178 (2006.01) A61K 31/4184 (2006.01) A61K 31/519 (2006.01) A61P 9/12 (2006.01)

Patent

CA 2426674

Preventives/remedies for portal hypertension containing compounds represented by the general formula (I), salts thereof or prodrugs of the same are provided. In said formula, R1 represents a group capable of forming an anion; X represents a bond or a spacer; n is an integer of 1 or 2; the ring A is an optionally substituted benzene ring; R2 represents a group capable of forming an anion; and R3 represents optionally substituted hydrocarbyl which may bonded via a hetero atom. These drugs are sufficiently excellent as medicines, since they have favorable preventive and therapeutic effects on portal hypertension without any side effect.

L'invention concerne des agents préventifs /remèdes destinés à l'hypertension portable et comprenant des composés représentés par la formule générale suivante (I), ainsi que des sels ou des promédicaments de ceux-ci. Dans cette formule, R?1¿ représente un groupe capable de former un anion; X désigne une liaison ou un espaceur; n représente un nombre entier égal à 1 ou 2; le noyau A désigne un noyau benzénique éventuellement substitué; R?2¿ désigne un groupe capable de former un anion; et R?3¿ représente un hydrocarbyl éventuellement substitué pouvant être lié via un hétéroatome. Ces composés sont d'excellents médicaments, étant donné qu'ils ont des effets préventifs et thérapeutiques favorables sur l'hypertension portable et ne présentent pas d'effets secondaires.

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