C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 16/32 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) C07K 16/18 (2006.01) C12N 5/10 (2006.01) C12N 15/02 (2006.01) C12P 21/08 (2006.01)
Patent
CA 2666249
Disclosed is a human monoclonal antibody directed against a protein having an amino acid sequence that is the same as or substantially the same as the amino acid sequence depicted in SEQ ID NO:1 or 3, a partial peptide of the protein, or a salt of the protein. The human monoclonal antibody is useful as a prophylactic or therapeutic agent for cancer, a cancer cell apoptosis promoter, a cancer cell proliferation inhibitor, a cytotoxic agent for a cancer cell which utilizes a biodefense mechanism via a Fc region of an antibody, or the like.
La présente invention concerne un anticorps monoclonal humain dirigé contre une protéine ayant une séquence d'acides aminés qui est la même ou essentiellement la même que la séquence d'acides aminés décrite dans la SEQ ID NO : 1 ou 3, un peptide partiel de la protéine, ou un sel de la protéine. L'anticorps monoclonal humain est utile comme agent prophylactique ou thérapeutique pour le cancer, promoteur de l'apoptose de la cellule cancéreuse, inhibiteur de la prolifération de la cellule cancéreuse, agent cytotoxique pour une cellule cancéreuse qui utilise un mécanisme de biodéfense via une région Fc d'un anticorps, ou équivalents.
Kurokawa Tomofumi
Oshima Tsutomu
Sato Shuji
Fetherstonhaugh & Co.
Takeda Pharmaceutical Company Limited
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