Agent for prevention and/or treatment of asthma

A - Human Necessities – 61 – K

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Details

A61K 48/00 (2006.01) A61K 31/519 (2006.01) A61K 31/55 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61P 11/06 (2006.01) A61P 43/00 (2006.01) C07H 21/00 (2006.01) C07K 14/705 (2006.01) C12N 15/12 (2006.01)

Patent

CA 2496573

Preventive and/or therapeutic drugs for asthma containing as the active ingredient substances capable of suppressing the functions of GPR4 relating to signal transduction; and preventive and/or therapeutic drugs for asthma containing as the active ingredient nitrogen-containing tricyclic compounds represented by the general formula (I), quaternary ammonium salts thereof, or pharmacologically acceptable salts of both: (I) wherein R1 is substituted or unsubstituted lower alkyl or the like; R2 is hydrogen, substituted or unsubstituted lower alkyl, or the like; R3 and R4 are each independently hydrogen, lower alkyl, or the like; n is 0 or 1; X is -(CH2)2- or the like; and Y is a group represented by the general formula (II): (II) (wherein W is CH or nitrogen; Z1 and Z2 are each independently hydrogen, substituted or unsubstituted lower alkyl, or the like; and Z3 is hydrogen, substituted or unsubstituted lower alkyl, or the like).

L'invention concerne des médicaments préventifs et/ou thérapeutiques contre l'asthme renfermant, comme ingrédient actif, des substances capables de supprimer les fonctions de GPR4 correspondant à la transduction des signaux ; ainsi que des médicaments préventifs et/ou thérapeutiques contre l'asthme renfermant, comme ingrédient actif, des composés tricycliques contenant de l'azote représentés par la formule générale (I), leurs sels d'ammonium quaternaire, ou des sels de qualité pharmaceutique de ces composés et de ces sels. Dans la formule générale (I), R?1¿ désigne un alkyle inférieur substitué ou non, ou analogue ; R?2¿ désigne un atome d'hydrogène, un alkyle inférieur substitué ou non, ou analogue ; R?3¿ et R?4¿ désignent chacun indépendamment un atome d'hydrogène, un alkyle inférieur, ou analogue ; n vaut 0 ou 1 ; X désigne -(CH¿2?)¿2?- ou analogue ; et Y désigne un groupe représenté par la formule générale (II) (dans laquelle W désigne CH ou un atome d'azote ; Z?1¿ et Z?2¿ désignent chacun indépendamment un atome d'hydrogène, un alkyle inférieur substitué ou non, ou analogue ; et Z?3¿ désigne un atome d'hydrogène, un alkyle inférieur substitué ou non, ou analogue).

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