Agent for promoting corneal endothelial cell adhesion

Details Agent for promoting corneal endothelial cell adhesion Agent for promoting corneal endothelial cell adhesion

C - Chemistry, Metallurgy

12

N

C12N 5/071 (2010.01) A61K 35/44 (2006.01) A61K 45/00 (2006.01) A61P 27/02 (2006.01)

Patent

CA 2697895

Provided is a means capable of efficiently growing corneal endothelial cells and a means of stably supplying a corneal endothelial preparation. An agent for promoting adhesion of a corneal endothelial cell, containing a Rho kinase inhibitor, a culture medium for a corneal endothelial cell, containing a Rho kinase inhibitor, a solution for preservation of cornea, containing a Rho kinase inhibitor, and a method of producing a corneal endothelial preparation, including a step of culturing the corneal endothelial cell using the above culture medium.

La présente invention concerne un moyen permettant de faire proliférer efficacement les cellules endothéliales cornéennes et un moyen permettant d'élaborer stablement une préparation endothéliale cornéenne. L'invention concerne un agent destiné à favoriser l'adhérence cellulaire endothéliale cornéenne, lequel agent contient un inhibiteur de Rho kinase ; un milieu de culture liquide pour cellules endothéliales cornéennes qui contient un inhibiteur de Rho kinase ; une solution de préservation de la cornée qui contient un inhibiteur de Rho kinase ; et un procédé de production d'une préparation endothéliale cornéenne qui comprend l'étape consistant à cultiver des cellules endothéliales cornéennes au moyen du milieu de culture liquide tel que décrit plus haut.

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