A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/16 (2006.01) A23K 1/16 (2006.01) A23L 1/305 (2006.01) A61K 38/01 (2006.01) A61K 38/36 (2006.01) A61P 19/08 (2006.01) A61P 19/10 (2006.01)
Patent
CA 2539445
It is intended to provide a novel agent for promoting osteogenesis and/or inhibiting bone resorption, which can be directly and orally taken over a long time in daily meals without any problems in preference, exerts effects of promoting osteogenesis and inhibiting bone resorption directly on bones and, therefore, is expected as efficacious in preventing or ameliorating/treating various bone diseases, as well as foods, drinks, drugs or feeds for promoting osteogenesis and/or inhibiting bone resorption. The above agent comprises, as the active ingredient, at least one substance selected from among .beta.2 microglobulin, histone, complement component 3, monocyte chemotactic protein 1, lysozyme, ribonuclease, prothrombin, cytochrome P-450, plasminogen, transferrin, thrombin, plasmin, complement component 4, .beta. defensin and enzymatic digestion products thereof. These substances have an effect or remarkably inhibiting bone resorption by osteoclasts and/or promoting osteogenesis via promotion of the proliferation and differentiation of osteoblasts.
L'invention concerne un nouvel agent destiné à activer l'ostéogenèse et/ou l'inhibition de la résorption osseuse, ledit agent pouvant être pris directement et par voie orale sur une longue période lors des repas quotidiens, sans aucun problème. Il exerce des effets d'activation de l'ostéogenèse et d'inhibition de la résorption osseuse, directement sur les os, laissant ainsi prévoir son efficacité dans la prévention ou l'amélioration et le traitement de diverses maladies osseuses. L'invention concerne en outre des aliments, des boissons ou des médicaments pour l'activation de l'ostéogenèse et/ou l'inhibition de la résorption osseuse. L'agent précité comprend, comme ingrédient actif, au moins une substance choisie à partir de la .beta.¿2? microglobuline, histone, composant complément 3, protéine 1 monocyte chimiotactique, lysozyme, ribonucléase, prothrombine, cytochrome P-450, plasminogène, transferrine, thrombine, plasmine, composant complément 4, .beta. défensine et produits de digestion enzymatiques de celle-ci. Ces substances ont un effet d'inhibition remarquable de résorption osseuse par ostéoclaste et/ou activation de l'ostéogenèse via l'activation de la prolifération et de la différentiation des ostéoblastes.
Kawakami Hiroshi
Matsuyama Hiroaki
Morita Yoshikazu
Motouri Mutsumi
Serizawa Atsushi
Dennison Associates
Megmilk Snow Brand Co. Ltd.
Snow Brand Milk Products Co. Ltd.
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