Agent for prophylaxis and treatment of angiostenosis

Details Agent for prophylaxis and treatment of angiostenosis Agent for prophylaxis and treatment of angiostenosis

A - Human Necessities

61

K

A61K 31/44 (2006.01) A61K 31/00 (2006.01) A61K 31/437 (2006.01) A61K 31/4409 (2006.01) A61K 31/445 (2006.01) A61P 9/00 (2006.01) C07D 213/75 (2006.01) C07D 213/81 (2006.01)

Patent

CA 2369552

Preventives/remedies for angiostenosis which contain compounds having an Rho kinase inhibitory activity. Compounds having an Rho kinase inhibitory activity such as (+)-trans-4-(1-aminoethyl)-1-(4-pyridylcarbamoyl)cyclohexane have various effects of suppressing the proliferation of endometrium regenerated after vascular lesion and the like. Owing to these effects, the above compounds are useful as preventives/remedies for angiostenosis, more particularly, angiostenosis induced by vascular wall lesion (for example, angiorestenosis following percutaneous coronary arterioplasty, angiorestenosis following percutaneous arterioplasty, angiostenosis following revascularization by indwelling a DCA or a stent, and angiostenosis following organ transplantation).

La présente invention concerne des compositions préventives/traitements contre l'angiosténose renfermant des composés ayant une activité inhibitrice de la Rho kinase. Les composés ayant une activité inhibitrice de la Rho kinase tels que (+)-trans-4- (1-aminoéthyl)-1-(4-pyridylcarbamoyl)cyclohexane présentent des effets variés de suppression de la prolifération de l'endomètre régénéré après une lésion vasculaire et analogue. Grâce à ses effets, les composés précités sont utilisés pour empêcher/traiter l'angiosténose, plus particulièrement, l'angiosténose induite par une lésion de paroi vasculaire (par exemple, l'angiosténose suite à une artérioplastie coronaire percutanée, l'angiosténose suite à une artérioplastie percutanée, l'angiosténose suite à une revascularisation par fixation à demeure d'un DCA ou d'un tuteur, et enfin, l'angiosténose suite à une transplantation d'organe).

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