Agent for prophylaxis and treatment of diabetic complications

Details Agent for prophylaxis and treatment of diabetic complications Agent for prophylaxis and treatment of diabetic complications

A - Human Necessities

61

K

A61K 31/415 (2006.01) A61K 31/4164 (2006.01) C07D 233/54 (2006.01) C07D 521/00 (2006.01)

Patent

CA 2241856

The present invention relates to an agent for the prophylaxis and treatment of diabetic complications comprising, as an active ingredient, 4-[.alpha.-hydroxy-2-methyl-5-(1-imidazolyl)benzyl]-3,5-dimethylbenzoic acid, an optically active compound thereof or a pharmaceutically acceptable salt thereof. The present invention further relates to a method for the prophylaxis and treatment of diabetic complications comprising administering an effective amount of this compound. The medicament of the present invention is useful for the prophylaxis and treatment of diabetic complications, namely, diabetic neuropathy, nephropathy, ophthalmopathy, arteriosclerosis and the like. The action of the drug is long lasting for very small doses and a single administration a day is sufficient.

L'invention se rapporte à des composés de prévention/traitement s'appliquant aux complications de diabètes contenant comme ingrédient actif l'acide 4-[ alpha -hydroxy-2-méthyle-5-(1-imidazolyle)benzyle]-3,5-dimétylbenzoïque, des isomères optiques de celui-ci ou des sels pharmaceutiquement acceptables de celui-ci; l'invention se rapporte également à un procédé de prévention ou de traitement de complications de diabètes qui consiste à administrer les composés mentionnés ci-dessus selon un dosage efficace. Ces médicaments sont utiles dans la prévention et le traitement de complications de diabètes telles que la neuropathie diabétique, la néphropathie, les troubles oculaires et l'arthériosclérose. Ils peuvent avoir de plus, des effets prolongés même dans une dose extrêmement petite ce qui permet de prendre ces médicaments uniquement une fois par jour.

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